A Preliminary clinical observation on the effect of the gel containing black raspberry extract on patients with persistent human papilloma virus infection
To investigate the negative rate and effectiveness of black raspberry extract in clearing persistent infection with human papilloma virus ( HPV), t hree hundred patients are included in the randomized, double blind, placebo controlled human trial for multicenter indication . The distribution ratio of the test ed group versus the control group is 2: 1 and the subject patients were given a preparation in the vagina before bed every other day, each dose was 3 g containing black raspberry extract (tested group) or placebo (control group). SPSS 20.0 was used for statistical analysis. Differences between groups were analyzed by the Rank Sum method or Chi square method. The results showed that 191 subjects in the tested group completed the trial , of which 139 subjects ( 72.8% were identified to have an effective clear ance of HPV ; 95 subjects in the control group completed the trial , of which only 15 subjects ( 15.8% were identified to have effective clearance of HPV. The difference between the two groups was statistically significant ( 2 = P 0.001 ). The HPV viral load of the tested group was decreased from 224.7 RLU/CO to 88.6 RLU/CO whereas HPV viral load of the control group was ascend ed from 218.4 RLU/CO to 266.1 RLU/CO Thus , the present clinical observation suggested that b lack raspberry extract may be a potential candidate in targeting persistent infection with HPV.