The enzymatic hydrolysates of Andrias davidianus mucus alleviates UVA-induced photoaging in the HSF cell and mouse skin

  • Li-Hua Zhou
  • Peng-Fei Zhang
  • Huan Zhang
  • Bei-Bei Gong
  • You-Nan Kou
  • Qing-Hua Luo
  • Wu-Yan Guo
  • Bo Zhang
  • Ke-Guo Deng
  • Jun-Hua Guo
  • Heng-Yu Zheng
  • Wu-Yan Guo
  • Bo Zhang
Keywords: Keywords: Andrias davidianus mucus; Photoaging; UVA; Oxidative stress; Active peptides.

Abstract

Photoaging is the premature aging of skin caused by long-term exposure to ultraviolet radiation. The skin mucus of Andrias davidianus has anti-photoaging activity, but its active ingredients and  mechanisms are not clear. In this study, we first investigated the photoprotective effect of enzymatic hydrolysates from Andrias davidianus mucus (AD-APRO) on UVA-irradiated responses in human skin fibroblasts (HSF) cells and mice. AD-APRO hindered the UVA induced activation of reactive oxygen species (ROS) and increased the activity of antioxidase in HSF cells. Furthermore, topical application of AD-APRO ameliorated skin photoaging in a mouse model by suppressing oxidative stress. CAMP and Peptide Ranker, two online tools, were used to predict the active peptides of AD-APRO against photoaging. The active peptides of AD-APRO were predicted to be KDACCNLVLHFNPRF, NLVLHFNPRF, FEWKP, and CNLVLHFNPRF. These results provide a basis for the study of the photoprotective effect of AD-APRO and suggest that it can be potentially used as an agent against UVA-induced skin photoaging in humans.

 

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Published
2023-12-31
How to Cite
Zhou, L.-H., Zhang, P.-F., Zhang, H., Gong, B.-B., Kou, Y.-N., Luo, Q.-H., Guo, W.-Y., Zhang, B., Deng, K.-G., Guo, J.-H., Zheng, H.-Y., Guo, W.-Y., & Zhang, B. (2023). The enzymatic hydrolysates of Andrias davidianus mucus alleviates UVA-induced photoaging in the HSF cell and mouse skin. Journal of Food Bioactives, 24. https://doi.org/10.31665/JFB.2023.18365
Section
Original Research