Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Review

Volume 19, September 2022, pages 136-142

Synthetic pathways of sinensetin and derivatives as an alternate source in biological activity study

Figures

Figure 1.
Figure 1. (a) Chemical structure of sinensetin and (b) number of annually published papers related to or focused on sinensetin since 1985 from the Web of Science (last search in June 2022).
Figure 2.
Figure 2. Synthetic pathways of sinensetin used by (a) Hossain and Ismail (2004) and (b) Wei et al. (2013).
Figure 3.
Figure 3. One-step synthesis of 5-demethylsinensetin.
Figure 4.
Figure 4. (a) Synthetic pathways of 3′-demethylsinensetin and 4′-demethylsinensetin by Wang et al. (2021) and (b) potential alternate routes to 16a, 16b and 3′,4′-didemethylsinensetin 16c (Li et al., 2006; Li et al., 2007).
Figure 5.
Figure 5. The synthetic pathway of 6-D3-sinensetin (Wei et al., 2013).
Figure 6.
Figure 6. Synthetic pathways of 5,3′-didemethylsinensetin (24a), 5,4′-didemethylsinensetin (24b) and 5,3′,4′-tridemethylsinensetin (24c).

Table

Table 1. Sinensetin content in the peels of different citrus cultivars
 
Citrus CultivarsRegionPeel (mg/kg)Reference
Citrus aurantium L. (bitter orange)Korea19.7 ± 0.1Park et al., 2014
Citrus reticulata L. (mandarin)Jamaica557 ± 20Green et al., 2007
Citrus reticulata L. var. (tangerine)Jamaica4,494 ± 100Green et al., 2007
Citrus sinensis cv. ‘Valencia’Jamaica4,253 ± 130Green et al., 2007
Citrus sinensis cv. ‘Parson Brown’Jamaica1,901 ± 40Green et al., 2007
Citrus sinensis cv. ‘Navel’Jamaica3,570 ± 60Green et al., 2007
Citrus aurantifolia (lime)Jamaica414 ± 8Green et al., 2007
Citrus limon (L.) Burm.f. cv. ‘Pangdelusaningmeng’China12.91 ± 1.10Xi et al., 2017
Citrus limon (L.) Burm.f. cv. ‘Feiminailao’China19.27 ± 1.32Xi et al., 2017
C. unshiu Marcov. × C. sinensis Osbeck (Kiyomi)Korea2,251 ± 87Han et al., 2012
C. unshiu Marcov. (Satsuma mandarin)Korea89 ± 14Han et al., 2012