Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Prospective

Volume 16, December 2021, pages 3-7

Potential target for mitigation of COVID-19 by food-derived bioactive peptides

Table

Table 1. Potential targets for food-derived peptides and related compounds to decrease potential risk of COVID-19
 
TargetsActionPotential active peptides and related compoundsReferences on active compounds*
*These studies have not demonstrated direct action on COVID-19, but demonstrated the suggested actions.
Angiotensin converting enzyme (ACE)Suppression of angiotensin II-induced inflammation and hypertensionVal-Tyr;
Ile-Pro-Pro		Matsui et al., 2002; Dong et al., 2013
Type II transmembrane serine proteases (TMPRSS2)Inhibition of SARS-CoV-2 entry into cellConcept only
FurinInhibition of SARS-CoV-2replication in cellConcept only
Host antiviral peptideEnhance host anti-viral peptides (α-defensin); Enhance host anti-viral peptides (β-defensin); Enhance host anti-viral peptides lactoferrinpyroGlu-Leu;
Concept only;
Concept only		Shirako et al., 2019;
Glutathione depletionSupplying glutathione; Supplying precursor of glutathione; Retaining hepatic cysteine by suppressing generation of aldehydesGlutathione;
N-acetyl-cysteine;
Phenethylamine		Yamada et al., 2018; Yamada et al., 2018; Zheng et al., 2021