Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
Journal website www.isnff-jfb.com

Original Research

Volume 6, June 2019, pages 110-117

Potential cardioprotective peptides generated in Spanish dry-cured ham

Figures

Figure 1.
Figure 1. Anti-inflammatory activity of the dry-cured ham peptides expressed as a) platelet-activating factor-acetylhydrolase (PAF-AH) inhibitory activity, b) autotaxin (ATX) inhibitory activity, and c) lipoxygenase (LOX) inhibitory activity. Bar letters indicate significant differences among the values at P < 0.05.
Figure 2.
Figure 2. Antioxidant activity of the dry-cured ham peptides determined by a) oxygen radical absorbance capacity (ORAC) assay, and b) ABTS radical scavenging capacity. Bar letters indicate significant differences among the values at P < 0.05.
Figure 3.
Figure 3. Angiotensin I-converting enzyme (ACE-I) inhibitory activity of the dry-cured ham peptides. Bar letters indicate significant differences among the values at P < 0.05.

Table

Table 1. Peptides previously identified in Spanish dry-cured ham and synthetised for testing their bioactivity
 
PeptideProtein of originSource*Previously assayed bioactivityReferences
*Type of dry-cured ham and curing time (in months) in which the peptide has been identified.
AAATPAllantoicaseSpanish dry-cured ham (10m)ACE inhibitorEscudero et al. (2013a)
AMNPPMyosin-3Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
IAGRPTitinTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
IKLPPMyosin-IXbTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
KPGRPTitinTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
KVLPGPhosphoglycerate kinase 1Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
PAPPKMyosin light chain 1/3Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
PSNPPTitinTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
TGLKPAspartate aminotransferaseTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
AAATPLEpithelial splicing regulatory protein 2Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
AAPLAPMyosin-XVTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
DVITGAMyosin light chain phosphorylatableSpanish dry-cured ham (10m)ACE inhibitorEscudero et al. (2013a)
EEYPDLCreatine kinaseSpanish dry-cured ham (10m)—Escudero et al. (2013a), Mora et al. (2014)
GGVPGGElastinSpanish dry-cured ham (10m)AntioxidantMora et al. (2014)
KAAAAPMyosin light chain 3Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
KPVAAPMyosin-XVTeruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
MDPKYRTitinSpanish dry-cured ham (10m)AntilisterialCastellano et al. (2016)
MPAWPIAspartate b-hydroxylase domain-containing prot 1Spanish dry-cured ham (10m)AntioxidantMora et al. (2014)
TKYRVPTitinSpanish dry-cured ham (10m)AntilisterialCastellano et al. (2016)
KAAAATPPR domain zinc finger protein 2Teruel dry-cured ham (14m), desaltedACE inhibitorEscudero et al. (2014)
AEEEYPDLCreatine kinaseSpanish dry-cured ham (10m)AntioxidantMora et al. (2014), Gallego et al. (2018)
HCNKKYRSEMDynein heavy chain 3Spanish dry-cured ham (10m)AntilisterialCastellano et al. (2016)
TSNRYHSYPWGSerine/threonine-protein kinaseSpanish dry-cured ham (10m)AntilisterialCastellano et al. (2016)
FNMPLTISRITPGSKALIM domain-binding protein 3Spanish dry-cured ham (9m)—Gallego et al. (2014b)