Journal of Food Bioactives, ISSN 2637-8752 print, 2637-8779 online
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Volume 6, June 2019, pages 1-5

Guarana as a source of bioactive compounds


Table 1. Studies in vitro or in vivo about health effects of guarana
Health effectsIn vitro/in vivoDoseReferences
Effects on metabolic comorbidities (obesity, hypertension, type 2 diabetes, and metabolic syndrome)In vivo: elderly humansTwice or more times a weekKrewer et al. (2011)
Oxidative stress and metabolic disorders (effects on the oxidation of LDL-c)In vivo: blood samples of elderly humans; In vitro: isolated LDL-cIn vivo: at least 5 times per week In vitro: 0.05, 0.1,0.5,1, and 5 µg·mL−1;Portella et al. (2013)
Oxidative stressIn vivo: overweight humans; Ex vivo: oxidation of LDL-c and total plasma antioxidant capacityIn vivo: 3 g of the powder diluted in 300 ml of water before intake, daily for 15 days before breakfastYonekura et al. (2016)
AntihyperglycemicIn vitro: inhibition of activity of carbohydrate-hydrolyzing enzymes (α-amilase and α-glucosidase)Guarana extracts after in vitro digestion α-amilase: 0.315, 0.525 and 0.875 mg·mL−1); α-glucosidase: 0.4 and 0.8 mg·mL−1Silva et al. (2018)
Gut microbial composition and redox and inflammatory parametersIn vivo: Wistar ratsGuarana seed powder the major compounds are caffeine (34.19 ± 1.26 mg·g−1), theobromine (0.14 ± 0.01 mg·g−1), (+)- catechin (3.76 ± 0.12 mg·g−1), and (−)-epicatechin (4.05 ± 0.16 mg·g−1)Silveira et al. (2018)
Antimicrobial activityIn vitro: antibacterial potential of the guarana extracts against Streptococcus mutansThe aqueous extract (AqE) from the 5% (w/v) guarana seeds; crude (EBPC) extracts and semi-purified (EPA and EPB) fractionsYamaguti-Sasaki et al. (2007)
Cognitive performance and mental fatigueIn vivo: healthy young adultsvitamin/mineral/guarana combinationKennedy et al. (2008)
Mood, cognitive performance and functional brain activationIn vivo: healthy young adultsvitamin/mineral/guarana combinationScholey et al. (2013)
Antiproliferative effectIn vitro: breast cancer cells MCF-7Guarana extracts 1, 5 and 10 µg·mL−1Hertz et al. ( 2015)
Anticancer effectIn vivo: female C57Bl/6 mice2.0 mg·g−1 body weightFukumasu et al. (2008)
Antitumor effectIn vitro: Colorectal and breast cancer cell lineages HT-29 and MCF-7 cells0.1, 1, 10, and 100 µg·mL−1Cadoná et al. (2017)