TY - JOUR AU - Won Young Oh AU - Yi-Shiou Chiou AU - Min-Hsiung Pan AU - Fereidoon Shahidi PY - 2019/09/30 Y2 - 2024/03/28 TI - Lipophilised resveratrol affects the generation of reactive nitrogen species in murine macrophages and cell viability of human cancer cell lines JF - Journal of Food Bioactives JA - JFB VL - 7 IS - 0 SE - Original Research DO - 10.31665/JFB.2019.7201 UR - http://www.isnff-jfb.com/index.php/JFB/article/view/112 AB - Resveratrol was esterified with selected fatty acids to improve its lipophilicity and potential application in food and biological systems. In this study, resveratrol and monoesters of resveratryl propionate (RC3:0) and resveratryl docosahexaenate (RDHA) were examined for their effects on anti-inflammatory and anti-proliferative activity in vitro.  All test compounds showed a decreased nitrite production in murine RAW 264.7 cells in a concentration dependent manner. Resveratrol, RC3:0, and RDHA were evaluated for their effects on cell viability using liver cancer (HepG2), colon cancer (HT-29, A431), breast cancer (MCF7), and gastric cancer (AGS) cell lines. All test compounds showed decreased cell viability of HepG2, A431, MCF7, HT-29, and AGS in a concentration-dependent manner. The results suggest that resveratrol esters may serve as potential anti-inflammatory and anti-proliferative agents. ER -